Feeling Seasick?

Oceans cover most of our planet, yet we know very little about marine ecosystems and even less about their pathogens and how they might infect us. When virologist Alvin Smith was working as a veterinarian for the U.S. Navy, he found that one marine virus called Vesivirus was causing a multitude of symptoms in a very wide range of animals - and could also spread from animals to humans. More recently, along with a team of researchers from Oregon State University, Eastern Virginia Medical School and AVI BioPharma, he has been studying how prevalent Vesivirus is in the general human population.

Vesivirus can infect a broad range of species due to an adaptive trait that has developed based on its replication mechanisms. Part of a family of viruses called Calciviruses, its genetic information is coded with RNA, not DNA. RNA replication lacks the proofreading inherent in DNA replication, making it very error-prone. Every virus replicated will have one to ten mistakes in the genetic code. Thus, the children from a single parent will virtually all be unique variants.

Although Vesivirus is present in the ocean, it can easily get to the surface. Much like the spray that comes off a freshly poured glass of soda, it can become airborne by erupting in bubbles at the surface of the water. "If you think about it, the ocean is a much easier place for a virus to get around anyway," says Smith. "When the viruses are shed, they're in basically a big bag of saline, so they can move around pretty freely and don't decay nearly as rapidly as they might on land."

Smith's theory was that many people could be unknowingly infected by the virus. It does not have a specific set of symptoms and can sometimes manifest itself simply as a blister - as exemplified by two scientists a few years ago who contracted the virus, one in the lab and one by working with marine mammals in the field. "If you don't know it's there, and you don't know to test for it, then it simply doesn't exist," says Smith.